Key findings: Comorbidities most associated with severe disease are diabetes, chronic kidney disease, chronic liver disease, cancer, solid organ transplant, frailty, severe mental illness, learning disabilities, Down’s Syndrome, rheumatoid arthritis, systemic lupus erythematosus and other immunosuppressive conditions, neurological conditions, cardiovascular disease, stroke, chronic obstructive pulmonary disease, smoking, and overweight and obesity.

Most pregnant women experience asymptomatic or mild disease that does not impact on their pregnancy. The risk of hospital admission with COVID-19 is increased in pregnant women from a minority ethnic background. There is emerging evidence that pregnant women may be at greater risk of severe disease requiring admission to intensive care and/or need for invasive ventilation than non-pregnant women, particularly in the third trimester. COVID-19 may increase the risk of preterm birth and admission to a neonatal care unit.

See this part of the guidance in the full evidence review here.

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